Thrombotic Thrombocytopenic Purpura (TTP) in children — a deep clinical review
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Abstract
Thrombotic Thrombocytopenic Purpura (TTP) is a rare but life-threatening hematologic disorder characterized by microangiopathic hemolytic anemia, thrombocytopenia, and microvascular thrombosis resulting from severe ADAMTS13 deficiency. Although classically seen in adults, TTP can occur in children as either congenital (hereditary) or acquired (immune-mediated) forms. Pediatric TTP presents diagnostic and therapeutic challenges due to its rarity, overlapping features with hemolytic uremic syndrome (HUS), and variable clinical manifestations ranging from neurological dysfunction to renal impairment.
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References
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