Liposomes for the Delivery of Antioxidants for Cutaneous Application. Development Strategies and Optimization of Their Preparation
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Abstract
Antioxidants (AOs) play a crucial role in the protection and maintenance of skin health. However, most of them are sensitive due to their instability and insolubility. The use of liposomes to protect AOs and expand their applicability to cosmeceuticals is one of the most effective solutions. Notwithstanding their offered advantages for the delivery of AOs, liposomes present many challenges in their production and application. Here, we provide a critical review of the major problems complicating the development of liposomes for AO delivery. Along with issues related to preparation techniques and encapsulation efficiency, the loss of protective function and inefficiency of skin permeability are the main disadvantages of liposomes. Corresponding development strategies for resolving these problems are introduced and discussed.
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