Study of mutations in the rpoB gene using molecular-genetic methods in samples obtained from patients with rifampicin-resistant strains in the Republic of Azerbaijan

Article Sidebar

PDF
Number of views 193

Published: Jan 20, 2026
DOI: https://doi.org/10.51582/interconf.19-20.01.2026.010
Keywords:
rpoB mutations, rifampicin resistance, MTBDRplus
Issue
No. 65(279) (2026): 10th ISPC «Scientific Trends and Trends in the Context of Globalization» (January 19-20, 2026; Umeå, Sweden).
Section
Medicine and Pharmacy
Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Main Article Content

Ilyaszada A.R.
Azerbaijan Medical University; Republic of Azerbaijan
Mammadova K.S.
Azerbaijan Medical University; Republic of Azerbaijan
Isayeva A.Ə.
Azerbaijan Medical University; Republic of Azerbaijan

Abstract

We analyzed rpoB mutations in rifampicin-resistant M. tuberculosis in Azerbaijan using MTBDRplus; Ser531Leu predominated, informing improved diagnostics and regimens.


Google Scholar

CrossRef

OUCI

Scilit

WorldCat

Index Copernicus

Semantic Scholar


Article Details

How to Cite
Ilyaszada, A., Mammadova, K., & Isayeva, A. (2026). Study of mutations in the rpoB gene using molecular-genetic methods in samples obtained from patients with rifampicin-resistant strains in the Republic of Azerbaijan . Scientific Collection «InterConf+», (65(279), 123–127. https://doi.org/10.51582/interconf.19-20.01.2026.010

References

N. Alixanova, I. Akhundova, M. Seyfaddinova, et al. First national survey of anti-tuberculosis drug resistance in Azerbaijan and risk factors analysis. Public Health Action. vol.4, supplement 2, 2014, pp.17-23. DOI: https://doi.org/10.5588/pha.14.0049

N. Selimova. PhD Thesis: Molecular-genetic criteria of multidrug-resistant M. tuberculosis in newly diagnosed tuberculosis patients. Baku, 2012.

Zh. T. Isakova. Frequency and types of mutations in rpoB, katG, inhA, ahpC genes associated with rifampicin and isoniazid resistance in M. tuberculosis strains circulating in Kyrgyzstan. Mol. Genet., Microbiol. Virol., 2008, № 4, pp.36-38. DOI: https://doi.org/10.3103/S0891416808040083

E. L. Isaeva. Genetic mutations of M. tuberculosis responsible for rifampicin resistance in tuberculosis patients: identification and characterization. Dissertation, Moscow, 2002.

V.M. Mikhailovich, S.A. Lapa, D.A. Gryadunov, et al. Use of hybridization and PCR methods on specialized TB microchip for detecting rifampicin-resistant M. tuberculosis strains. Bull. Exp. Biol. Med., 2001, № 1, pp.112-117.

V.N. Stepanshina, E.A. Panfertsev, G.N. Mitrofanova, et al. Molecular mechanisms of resistance to rifampicin and isoniazid in clinical strains of M. tuberculosis. Problems of Tuberculosis, 2000, № 1, pp.32-36.

N. Bodmer, G. Zurcher, I. Imboden, et al. Mutation position and type of substitution in the beta-subunit of RNA polymerase influence in-vitro activity of rifamycins in rifampicin-resistant M. tuberculosis. J. Antimicrob. Chemother., 1995, vol.35, pp.345-348. DOI: https://doi.org/10.1093/jac/35.2.345

Leu T., Zhao M., Li X., et al. Selection of mutations to detect multidrug-resistant M. tuberculosis strains in Shanghai, China. Antimicrob. Agents Chemother., 2010, vol.54, pp.1075-1081. DOI: https://doi.org/10.1128/AAC.00964-09

H. Ohno, H. Koga, S. Kohno, et al. Relationship between rifampicin MIC and rpoB mutations of M. tuberculosis strains isolated in Japan. Antimicrob. Agents Chemother., 1996, vol.40, pp.1053-1056. DOI: https://doi.org/10.1128/AAC.40.4.1053

A. Telenti, P. Imboden, F. Marchesi, et al. Detection of rifampicin-resistance mutations in M. tuberculosis. Lancet, 1993, vol.341, pp.647-650. DOI: https://doi.org/10.1016/0140-6736(93)90417-F

X. Wu, J. Zhang, Y. Zhuang, et al. Molecular mechanism of drug resistance in M. tuberculosis clinical isolates. Clin. Med. J., 1999, vol.112, № 6, pp.524-5