The gut microbiome and its role in obesity and metabolic disease

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Published: Aug 20, 2024
DOI: https://doi.org/10.51582/interconf.19-20.08.2025.016
Keywords:
gut microbiota, obesity, metabolic syndrome, short‑chain fatty acids, inflammation
Issue
No. 60(260) (2025): 11th ISPC «Current Issues and Prospects for The Development of Scientific Research» (August 19-20, 2025; Orléans, France).
Section
Medicine and Pharmacy
Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Main Article Content

Jabbar Robia
Poonch University Rawalakot; Pakistan
Azam Hammad
Semey Medical University; Republic of Kazakhstan

Abstract

Obesity is a global health problem driven by the complex interplay between genetic, environmental and microbial factors. Over the last decade, evidence from animal models and human studies suggests that the trillions of bacteria in our gastrointestinal tract act as a metabolic organ and influence energy harvest, fat storage and systemic inflammation. This review describes how early‐life events shape the adult gut microbiota, how microbial composition differs in obesity and metabolic syndrome, and the mechanistic pathways particularly short‑chain fatty acids, bile acid signalling and immune crosstalk through which the microbiota may promote or protect against obesity. Finally, current and emerging therapeutic strategies, such as dietary modulation, probiotics, prebiotics, antibiotics and faecal microbiota transplantation, are discussed.


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How to Cite
Robia, J., & Hammad, A. (2024). The gut microbiome and its role in obesity and metabolic disease. Scientific Collection «InterConf+», (60(260), 151–159. https://doi.org/10.51582/interconf.19-20.08.2025.016

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