Cost-effectiveness analysis of kidney transplantation versus dialysis in Ukraine: a comparative study
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Abstract
This study evaluates the cost-effectiveness of kidney transplantation compared to hemodialysis for treating end-stage renal disease in Ukraine. Using Markov modeling, the analysis assessed costs, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratio (ICER) over a 10-year horizon. Results showed that kidney transplantation provided 1.9 additional QALYs per patient compared to hemodialysis. The ICER for transplantation was $4,462 per QALY, falling within the World Health Organization's threshold for cost-effectiveness. Sensitivity analysis confirmed the economic viability of transplantation, even with potential cost increases for the government. Although transplantation had higher initial costs, it resulted in better survival rates and quality of life outcomes. The study concludes that prioritizing funding for kidney transplantation is strongly advised in Ukraine, as it is a cost-effective approach for managing ESRD. Limitations include the assumption of ideal transplantation conditions and the exclusion of comorbidities in survival estimates.
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References
Nyokabi, P., Youngkong, S., Bagepally, B. S., Okech, T., Chaikledkaew, U., McKay, G. J., Attia, J., & Thakkinstian, A. (2024). A systematic review and quality assessment of economic evaluations of kidney replacement therapies in end-stage kidney disease. Scientific reports, 14(1), 23018. https://doi.org/10.1038/s41598-024-73735-8 DOI: https://doi.org/10.1038/s41598-024-73735-8
Zhang, Y., Gerdtham, UG., Rydell, H. et al. (2023). Healthcare costs after kidney transplantation compared to dialysis based on propensity score methods and real world longitudinal register data from Sweden. Sci Rep 13, 10730. https://doi.org/10.1038/s41598-023-37814-6. DOI: https://doi.org/10.1038/s41598-023-37814-6
Kolesnyk, M., Kozliuk, N., & Razvazhaeva, O. (2022). Національному реєстру хворих на хронічну хворобу нирок та пацієнтів з гострим пошкодженням нирок 20 років: надбання та перспективи. Український Журнал Нефрології та Діалізу, (4(76), 3-9. https://doi.org/10.31450/ukrjnd.4(76).2022.01 DOI: https://doi.org/10.31450/ukrjnd.4(76).2022.01
Parii, V. D., & Hryshchuk, S. M. (2024). Cost-effectiveness of dialysis and kidney transplantation to treat end-stage renal disease in Ukraine. Wiadomosci lekarskie (Warsaw, Poland : 1960), 77(4), 765–771. https://doi.org/10.36740/WLek202404123. DOI: https://doi.org/10.36740/WLek202404123
Yang, F., Liao, M., Wang, P., Yang, Z., & Liu, Y. (2021). The Cost-Effectiveness of Kidney Replacement Therapy Modalities: A Systematic Review of Full Economic Evaluations. Applied health economics and health policy, 19(2), 163–180. https://doi.org/10.1007/s40258-020-00614-4. DOI: https://doi.org/10.1007/s40258-020-00614-4
Howell, M., Walker, R. C., & Howard, K. (2019). Cost Effectiveness of Dialysis Modalities: A Systematic Review of Economic Evaluations. Applied health economics and health policy, 17(3), 315–330. https://doi.org/10.1007/s40258-018-00455-2 DOI: https://doi.org/10.1007/s40258-018-00455-2
GDP per capita in Ukraine. https://data.worldbank.org/country/ukraine?view=chart.